Myint Swe
Royal College of Medicine Perak, MalaysiaTitle: Usefulness of in-house collected eggshell membrane for joint pain
Abstract
Eggshells are the waste product of the bakery business. But the eggshell membrane (ESM) collected from the hard eggshell is very useful for joint pain. ESM is a natural source of glucosamine, collagen, and hyaluronic acid, which are essential for cartilage health. ESM also possesses anti-inflammatory and immunomodulatory properties,that can reduce pain and improve joint function in OA patients. The hard eggshells are cleaned by using salty water. Those are blended and then separated the membrane by floatation method. The flakes of ESM are pasteurized to eliminate bacterial contamination, and then powdered it and packed it as a capsule containing 250 mg of ESM per capsule.
Fifty-four persons with OA were organized for voluntary participation in the clinical trial. They received two capsules of ESM daily for 30 days as a treatment. A questionnaire with a visual analogue scale (VAS) was used to measure their pain and stiffness levels at baseline and on the 10th, 30th, 60th, and 90th day after commencement of the treatment. The Friedman and post-hoc pairwise comparison Conover tests were used to test the significant reduction of the pain score. A P-value of 0.05 was taken as the significant limit. Of the fifty-four voluntary participants who enrolled in the study, three dropped out, resulting in a response rate of 94.4%. This study found that treatment with ESM significantly reduced pain scores for all 10 symptoms on day 30 compared to the initial baseline (P < 0.01). This improvement remained consistent on days 60 and 90 (P>0.05). Only one participant (1.9%) reported a 'warm sensation,' and no other adverse effects were reported. In-house collected ESM is a safe and effective alternative to glucosamine products for the management of OA.
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